Shape Therapeutics, Inc. (ShapeTX), a pre-clinical stage company with an industry-leading RNA targeting technology platform, announced today that Francois Vigneault, PhD., President & Chief Executive Officer, will highlight advances in their RNAfix™ ADAR editing platform, including data that demonstrates RNA editing up to ~90% in genes . Rewrite the future. The conference is being held virtually, October 1-2, 2020. The presentation will be on Friday, October 2, 2020 at 4 PM ET. Shape Therapeutics is a biotechnology company developing next-generation RNA-targeted therapies to treat the world's most challenging diseases. Shape Therapeutics is a biotechnology company developing next generation RNA-targeted therapies to treat the world’s most challenging diseases. Shape Therapeutics, Inc. (ShapeTX), a next-generation gene therapy company with an industry-leading RNA targeting technology platform, announces today the appointment of Gary Fortin as Chief Operating Officer (COO). 4These authors contributed equally. Powered by Madgex Job Board Software, https://www.businesswire.com/news/home/20200928005719/en/, http://www.businesswire.com/news/home/20200928005719/en. Shape Therapeutics. Shape Therapeutics is headquartered in Seattle, Washington with a satellite site in Cambridge, Massachusetts. Our unique platform, OPERA, is designed to solve many of the challenges facing current gene therapy and gene editing approaches, including safety and flexibility of delivery mechanisms. However, as ADAR-dsRNA interactions primarily rely on structure rather than sequence dependency, a major limitation of relying on enzyme overexpression is the propensity to introduce a plethora of off-target A-to-I edits across the . Shape Therapeutics is a biotechnology company developing next-generation RNA-targeted therapies to treat the world's most challenging diseases. Shape Therapeutics公司的研发管线（图片来源：Shape公司官网，点击可见大图） 两类RNA编辑的不同策略. It has been more than 25 years since the identification of the FMR1 gene and the demonstration of the causative role of CGG-repeat expansion in the disease pathology of fragile X syndrome (FXS), but the underlying mechanisms involved in the ... This book is a collection of eight articles, of which seven are reviews and one is a research paper, that together form a Special Issue that describes the roles that long noncoding RNAs (lncRNA) play in gene regulation at a post ... SEATTLE--(BUSINESS WIRE)--Shape Therapeutics, Inc. (ShapeTX), a pre-clinical stage company with an industry-leading RNA targeting technology platform, announced today that Francois Vigneault, PhD., President & Chief Executive Officer, will highlight advances in their RNAfix™ ADAR editing platform, including data that demonstrates RNA editing up to ~90% in genes implicated in Parkinson’s disease. To ensure the most secure and best overall experience on our website we recommend the latest versions of, Internet Explorer is no longer supported. Shape Therapeutics (Shape TX) launched an up-to-$3 billion collaboration with Roche in August to apply its RNA editing platform RNAfix™ and potentially leverage its AAVid™ technology platform . In this book, the first to study Beni-Amer practices, Zeremariam Fre argues for the importance of their knowledge, challenging the preconceptions that regard it as untrustworthy when compared to scientific knowledge from more developed ... John Suliman At ShapeTX, we are a dynamic team of professionals who are dedicated and passionate about making cures a reality. Akin to short-hairpin RNAs and antisense oligonucleotides which efficaciously recruit endogenous cellular machinery such as Argonaute and RNase H to enable targeted RNA knockdown, simple long antisense guide RNAs ( [1][1] ) can recruit endogenous adenosine deaminases acting on RNA (ADARs) to enable programmable A-to-I RNA editing, without requiring co-delivery of any exogenous proteins. . Apply to Research Associate, Management Associate, Senior Associate Scientist and more! Shape Therapeutics has raised $112 million in series B financing to further develop RNA editing and gene-therapy technologies. Shape Therapeutics is a biotechnology company developing breakthrough gene therapy technologies to treat the world's most challenging diseases. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent ... An assessment of cancer addresses both the courageous battles against the disease and the misperceptions and hubris that have compromised modern understandings, providing coverage of such topics as ancient-world surgeries and the ... In addition to supporting the development of multiple RNA platforms, the proceeds will also bankroll partnership opportunities for the Seattle-based biotech. I n the past couple of decades, groundbreaking research in the discipline of RNA biology has led to the development of a new class of biologics that constitute RNA therapeutics. Found inside – Page 23It could be shown that a target specific for the edited miRNA-376 sequence was upregulated in ADAR knockout mice (112). ... miRNA function or when contemplating the use of miRNAs as laboratory tools or for developing therapeutics. RNAfix TM, a precision RNA editing technology using endogenous Adenosine Deaminase Acting on RNA (ADAR); and AAVid TM, a next-generation engineered adeno-associated virus (AAV) platform producing . Investors & Media Shape Therapeutics, Inc. (ShapeTX), a next-generation gene therapy company with an industry-leading RNA targeting technology platform, announces today the unveiling of the AAVidTM capsid discovery . D.K. Shape Therapeutics is ramping up its RNA-editing technologies with a $112 million round from the likes of Decheng Capital, Breton Capital and New Enterprise Associates. 8月24日，Shape Therapeutics（以下简称"Shape"）宣布，与罗氏公司达成一项研发合作和许可协议。 来源：Shape. RNAfix TM, a precision RNA editing technology using endogenous Adenosine Deaminase Acting on RNA (ADAR); and AAVid TM, a next-generation engineered adeno-associated virus (AAV) platform producing . Shape Life! Shape Therapeutics, a biotech based in Seattle that launched in 2019, has developed a proprietary RNAfix technology that can precisely target a point or nonsense mutation. RNA编辑的生物学现象早在上世纪80年代就被发现，在1995年，Ribozyme Pharmaceuticals公司的研究人员就发现反义寡核苷酸可以募集ADAR酶到互补RNA链上进行碱基编辑。 Shape's RNA editing technology takes advantage of an enzyme called . . “The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. Shape Therapeutics Inc. (ShapeTX), a next-generation RNA-targeting gene therapy company, announces today the upcoming company presentation at the J.P. Morgan 39th Annual Healthcare Conference by Francois Vigneault, PhD., President and Chief Executive Officer. Shape Therapeutics is a biotechnology company developing next-generation RNA-targeted therapies to treat the world's most challenging diseases. John@shapetx.com, Internet Explorer presents a security risk. For example, ADAR disfavors editing an adenosine that has a guanine just upstream of it because the biophysics makes the interaction difficult.
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